Strong opioid painkillers like Tramadol work by replicating the effects of endorphins, which are endogenous substances that naturally reduce pain. The brain and spinal cord contain endorphins, which work with opioid receptors to lessen pain.
Tramadol interacts with the same opioid receptors in the brain and spinal cord as our natural endorphins to imitate their effects. In spite of the fact that the cause of the pain is still present, less pain is really felt as a result of blocking the passage of pain signals from the nerves to the brain.
Tramadol also makes several neurotransmitters in the brain and spinal cord more active. Chemical substances known as neurotransmitters serve as messengers between nerve cells. Tramadol helps to reduce pain by enhancing the effects of the neurotransmitters serotonin and norepinephrine.
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